TSE monitoring in wildlife epidemiology, transmission, diagnosis, genetics and control

bookPart

Machado, Carla Neves
Orge, Leonor
Pires, Isabel
Gama, Adelina
Esteves, Alexandra
Paula Mendonça, Ana
Matos, A.C.
Alves, Anabela
Lima, Carla
Bastos, Estela
Seixas, Fernanda
Silva, Filipe
Carlos Silva, João
Figueira, L.
Vieira-Pinto, Madalena
De Lurdes Pinto, Maria
Gonçalves-Anjo, Nuno
Tavares, Paula
Carvalho, Paulo
Sargo, Roberto
Pires, Maria dos Anjos

IntechOpen

Machado, C.N., Orge L., Pires, I., Gama, A., Esteves, A., Mendonça, A.P., Matos, A.C., Anabela Alves, A., Lima, C., Bastos, E., Seixas, F., Silva, F., Silva, J.C., Figueira, L, Vieira-Pinto, M, Pinto, M.L., Gonçalves-Anjo, N., Tavares, P., Carvalho, P., Sargo R., Pires, M.A.,2019. TSE Monitoring in Wildlife Epidemiology, Transmission, Diagnosis, Genetics and Control [Online First], IntechOpen, (April 30th 2019). DOI: 10.5772/intechopen.85797.

10.5772/intechopen.85797

TSE monitoring in wildlife epidemiology, transmission, diagnosis, genetics and control

Prion
Cervids
Chronic wasting disease
PRNP
Genepathology

2019-11-23T00:05:41Z
2019-11-23T00:05:41Z
2019

Among the transmissible spongiform encephalopathies (TSEs), chronic wasting disease (CWD) in cervids is now the rising concern within Europe. CWD will be outlined in this chapter gathering its epidemiology, transmission, diagnosis, genetics, and control. Prion diseases are fatal neurodegenerative diseases characterized by the accumulation of an abnormal isoform of the prion protein (PrPc), usually designated by PrPsc or prion. CWD is a prion disease of natural transmission affecting cervids detected mainly in North America. The first European case was detected in Norway, in 2016, in a wild reindeer; until April 2018, a total of 23 cases were described. The definite diagnosis is postmortem, performed in target areas of the brain and lymph nodes. Samples are first screened using a rapid test and, if positive, confirmed by immunohistochemistry and Western immunoblotting. It is not possible to establish a culling plan based on the genotype, once affected animals appear with all genotypes. However, some polymorphisms seem to result in longer incubation periods or confer a reduced risk. The control is not easy in captive cervids and even more in the wildlife; some recommendations have been proposed in order to understand the danger and impact of CWD on animal and public health.
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