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A partir de Fev. 06 a publicação tem ISBN e nº de Dep. Legal
Bibliografia p. 187
Contém: vol. 1 : História e geografia de Portugal
Dissertação de Mestrado em Design de Interiores apresentado à Escola Superior de Artes Aplicadas do Instituto Politécnico de Castelo Branco e à Faculdade de Belas-Artes da Universidade de Lisboa para obtenção do Grau de Mestre em Design de Interiores.
Contém referências bibliográficas
Contém referências bibliográficas
Contém referências bibliográficas
Modelo de desenvolvimento profissional
Modelo de desenvolvimento profissional
Dissertação de mestrado em Cuidados Paliativos. Instituto Politécnico de Castelo Branco, Escola Superior de Saúde Dr. Lopes Dias, 2018
Disponível na Biblioteca da ESACB na cota C30-17839TFCPAN.
Disponível na Biblioteca da ESACB na cota C30-25174TFCRNA.
Disponível na Biblioteca da ESACB na cota C30-24903TFCRNA.
Relatório de Estágio apresentado à Escola Superior de Educação do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Educação Pré-Escolar e Ensino do 1º Ciclo do Ensino Básico.
Relatório de Prática Clínica apresentado à Escola Superior de Saúde Dr. Lopes Dias do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Cuidados Paliativos.
Contém referências bibliográficas
Depressão pós-parto
Disponível na Biblioteca da ESACB na cota C30-27278TFCEA.
Formação profissional
Medicinal plants have been used since the earliest documented history around the
world, as an available and inexpensive therapeutic resource. Plant based bioactive
elements play eminent biological roles as antioxidant, anti-inflammatory and
antiproliferative agents. It is proved that naturally occurring antioxidants in
ethnomedicinal plants are effective in treating various types of diseases.
However, herbal medicine, without any knowledge of their toxicological profile,
target organ, and safe dose, is one of the biggest problems of recent health care systems.
Any drug or herbal formula which is intended to be used in humans must first be tested
in suitable experimental in vitro or animal models in order to evaluate its safety.
Therefore, it is of interest to evaluate the toxicity of plant extracts to enhance their value
for the pharmaceutical and cosmetic industries. Six extracts of plants
produced/endogenous in Portugal: Cistus ladanifer, Thymbra capitata, Helichrysum
italicum, Cupressus lusitanica, Ocimum basilicum and Matricaria chamomilla were used
in order to assess their reproductive toxicity by evaluating the viability of sperm when in
contact with the extracts. Hydrolates for each plant were obtained by hydrodistillation of
aerial parts. The chemical composition of the hydrolates was determined by GC-MS (gas
chromatography mass spectrometry).
Reproductive toxicity was assessed by exposing cryopreserved bovine semen to
six different concentrations of each hydrolate (0.2%-0.002% v/v). Methyl
methanesulfonate (MMS) was used (0.22nM) as positive control of sperm toxicity. After
incubation, sperm viability was determined for each concentration by staining with eosinnigrosin
and counting the number of viable and dead spermatozoa (spz) in a total of 200
spz.
The results show that the hydrolates in test do not compromise sperm viability for
all tested concentrations (>25%) when compared with negative control (34%) and in fact,
M. chamomilla seems to promote sperm viability (39%) at the highest tested
concentration.
These results indicate that the extracts at the concentrations used do not seem to
have a toxic effect on this evaluated target.
The demand for natural-based products for industrial applications is increasing sharply
and therefore the search for new alternatives to the plants traditionally used is growing.
These alternative plants can be an important source of bioactive compounds under a
circular economy approach. Considering the potential future use of new plant extracts
by the industry, it is necessary to assess the risk associated with their introduction into
the ecosystem. This work aims to provide an insight into the volatile profiles and
evaluate the potential (eco)toxic effects of essential oils (EO’s) and hydrolates of four
plant species, namely rockrose ( Cistus ladanifer ), curry plant ( Helichrysum italicum
), conehead thyme ( Thymbra capitata ) and basil ( Ocimum basilicum ). Chemical
analysis was performed by GC-MS and acute toxicity tests were performed using the
model organism Daphnia magna . The essential oil and the hydrolate from H. italicum
, as well as all the other hydrolates caused no immobilization up to the highest
concentrations tested, suggesting that all hydrolates present low to no risk towards D.
magna. Similarly, the essential oil of H. italicum , presented negligible risk towards
D. magna . For C. ladanifer and T. capitata essential oils, the EC 50 (the
concentration estimated to immobilize 50 per cent of the Daphnia ) at 48h varied from
199.7 mg/L and 12.05 mg/L, respectively. The essential oil from C. ladanifer was
mainly characterised by monoterpene hydrocarbons, while the H. italicum was richer
in sesquiterpene hydrocarbons. Both essential oil and hydrolate from T. capitata
contained exclusively monoterpene hydrocarbons with a particularly high content of
carvacrol. The higher acute toxicity of T. capitata essential oil can be attributed to the
high amount of carvacrol present in the distillate. Overall, of the essential oils and
hydrolates tested, all can be classified as practically non-toxic, except for T. capitata
essential oil that, according to the Globally Harmonized System of Classification and
Labelling of Chemicals (GHS) of the United Nations, can be classified as moderately
toxic
